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2019 Vol.31, Issue 3 Preview Page

Research Article

Effects of Ginseng Sprout Extract and Modified Kyung-Ok-Ko on Scopolamine-induced Cognitive Impairment in Mice

스코폴라민 유도 기억력 손상 모델에서 새싹산양삼과 이를 포함한 경옥고 가미방의 기억력 개선 효과

H. B. Park1
,
S. Y. Kim1
,
S. J. Park2*
박 현배1
,
김 소연1
,
박 세진2*
1Master’s Course, School of Natural Resources and Environmental Sciences, Kangwon National University
2Assistant Professor, School of Natural Resources and Environmental Sciences, Kangwon National University
* Corresponding Author
31 December 2019. pp. 151-159
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Abstract

As the world population ages, the number of patients with dementia is expected to increase dramatically in the future. Ginseng (Panax ginseng C.A. Meyer) has many effects such as control of nerve function, control of body fluids and metabolic function, anti-diuretic, sexual enhancement, resistance to stress, improvement of digestion and absorption, and immune boosting effects. Kyung-Ok-Ko is widely used in traditional Korean medicine. The aim of this study is to investigate memory-enhancing properties of 70% ethanolic extracts of ginseng sprouts and modified Kyung-Ok-Ko. Alzheimer’s disease was induced by scopolamine treatment (1 mg/kg, i.p.) in mice. Passive avoidance and Y-maze tasks were performed by the mice to determine the effects of ginseng sprout extract and modified Kyung-Ok-Ko on memory. Ginseng sprout extract and modified Kyung-Ok-Ko significantly enhanced cognitive function and reduced scopolamine- induced cognitive impairment in mice. Compared to Kyung-Ok-Ko, modified Kyung-Ok-Ko had a significant memory-enhancing effect at a lower dose. Our findings suggest that ginseng sprout extract and modified Kyung-Ok-Ko attenuate cognitive impairment in mice.

Keywords
Ginseng sprout
Memory
Modified Kyung-Ok-Ko
Passive avoidance task
Y-maze task
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Information
  • Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
  • Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
  • Journal Title :Journal of Agricultural, Life and Environmental Sciences
  • Journal Title(Ko) :농업생명환경연구
  • Volume : 31
  • No :3
  • Pages :151-159
  • Received Date : 2019-12-06
  • Revised Date : 2019-12-16
  • Accepted Date : 2019-12-16
  • DOI :https://doi.org/10.22698/jales.20190018
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