Effect of Wolfiporia extensa,  Atractylodes japonica,  and Paeonia lactiflora Extracts and Their Mixtures on Improving Hepatic Function and Hepatocyte Protection

Hee-Jun Kim; Bohye Kim; Mi-Ra Lee; Chang-Eun Kim; Soo-Hyun Kim; Bong-Hwan Chung; Moonjin Ra; Yongjun Lee

doi:10.22698/jales.20210021

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2021 Vol.33, Issue 3S Preview Page Next Page

Research Article

Effect of Wolfiporia extensa, Atractylodes japonica, and Paeonia lactiflora Extracts and Their Mixtures on Improving Hepatic Function and Hepatocyte Protection 복령, 백출, 작약 단독 및 혼합 추출물의 간건강 개선효과

31 October 2021. pp. 205-214

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Abstract

Herbal preparations are combinations of botanical extracts that are assumed to exert additive and synergistic effects. In this study, we investigated the effects of individual ethanol extracts of Wolfiporia extensa (TD1), Atractylodes japonica (TD2), Paeonia lactiflora (TD3), and mixtures thereof (TD4–TD7) on improvements in hepatic function and hepatocyte protection in human hepatocyte carcinoma (HepG2) cells. Prior to this experiment, we determined the appropriate dose for the treatment using TD1, TD2, TD3, and TD4–TD7 on the viability of HepG2 cells. Results showed that these extracts ameliorated cell toxicity against acetaminophen (APAP)-induced cell death in human hepatocyte carcinoma cells. Additionally, they significantly reduced lactate dehydrogenase (LDH) levels. We also evaluated the effect of TD1–TD7 on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. We found that treatment with TD1–TD7 slightly attenuated the increase in AST and ALT levels compared to APAP-treated HepG2 cells. These results indicate that Wolfiporia extensa, Atractylodes japonica, and Paeonia lactiflora extracts and their mixtures could help improve hepatic function and induce hepatocyte protection.

Keywords

Atractylodes japonica

Hepatic function

Hepatocyte protection

Paeonia lactiflora

Wolfiporia extensa

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Information

Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
Journal Title :Journal of Agricultural, Life and Environmental Sciences
Journal Title(Ko) :농업생명환경연구
Volume : 33
No :3
Pages :205-214
Received Date : 2021-09-24
Revised Date : 2021-10-16
Accepted Date : 2021-10-18
An Erratum to this article was published on 31 March 2022.

This article has been updated.
DOI :https://doi.org/10.22698/jales.20210021

Journal of Agricultural, Life and Environmental Sciences ISSN:2233-8322(Print) 2508-870X(Online) 농업생명환경연구

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