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2026 Vol.38, Issue 1 Preview Page

Research Article

Encapsulation of Coenzyme Q10 using OSA Starch and Surfactant: Implications for Storage Stability and Pharmacokinetic Profile
Da Hui Kim1
,
Jin Hyeok Choi1
,
Eun Hee Jang2
,
Jong-Yea Kim13*
1Researcher, Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea
2Researcher, Bio-convergence Engineering, Dongyang Mirae University, Seoul 08221, Korea
3Professor, Institute of Fermentation and Brewing, Kangwon National University, Chuncheon 24341, Korea
*Corresponding Author
31 March 2026. pp. 86-97
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Abstract

In this study, we developed a nano-encapsulation system using three types of octenyl succinic anhydride (OSA)-modified starches as wall materials to enhance the solubilization and delivery efficiency of Coenzyme Q10 (CoQ10). The OSA starches were categorized into high-viscosity (Sunfree) and low-viscosity (Purity Gum Ultra and EMCAP) groups. Low-viscosity carriers achieved superior particle uniformity with hydrodynamic diameters ranging from 225 to 240 nm. Specifically, Purity Gum Ultra exhibited exceptional solubilization capacity, maintaining nearly 100% solubility up to a CoQ10 concentration of 30 mg/mL. The starch-based encapsulation provided a robust interfacial barrier that effectively protected the CoQ10 core against chemical degradation under severe thermal stress (60－100°C) and across a wide pH range (3.0－9.0). Pharmacokinetic evaluation in a rat model revealed that the Purity Gum Ultra-based nano-capsules significantly enhanced systemic exposure, achieving an 8.48-fold increase in relative bioavailability compared to crystalline CoQ10.

Keywords
Aqueous solubilization
Coenzyme Q10
Pharmacokinetic
Storage stability
References
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Information
  • Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
  • Publisher(Ko) :None
  • Journal Title :Journal of Agricultural, Life and Environmental Sciences
  • Volume : 38
  • No :1
  • Pages :86-97
  • Received Date : 2026-02-05
  • Revised Date : 2026-02-19
  • Accepted Date : 2026-02-19
  • DOI :https://doi.org/10.22698/jales.20260007
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