Improvement Effect of Aceriphyllum rossii Extract on Dextran Sodium Sulfate-induced Colitis

Hee-Jun Kim; Bohye Kim; Mi-Ra Lee; Gye Chun Jo; Moonjin Ra; Yongjun Lee

doi:10.22698/jales.20230044

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2023 Vol.35, Issue 4 Preview Page Next Page

Research Article

Improvement Effect of Aceriphyllum rossii Extract on Dextran Sodium Sulfate-induced Colitis DSS로 유도된 궤양성 대장염 모델에서의 돌단풍 추출물의 장 건강 개선효과

31 December 2023. pp. 552-563

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Abstract

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the intestine characterized by recurrent chronic inflammation and mucosal damage in the gastrointestinal tract. Recent studies have demonstrated that Aceriphyllum rossii extract (ARE) contains abundant natural flavonoids and enhances the anticancer, antioxidant, and anti-inflammatory effects in various disease models. However, whether ARE has a protective effect against dextran sodium sulfate (DSS)-induced colitis remains unclear. In the present study, we investigated the effects of ARE treatment in a mouse model of colitis. Oral administration of DSS induced shortening of the colon and increased the disease activity index and histological damage. However, ARE treatment significantly attenuated IBD symptoms, such as weight loss, bloody stool, stool consistency, and histological damage in DSS-induced colitis. In addition, ARE treatment decreased colonic inflammatory cytokine (IL-6 and IL-22) levels. Collectively, these results suggest that ARE treatment can help improve colonic function and prevent IBD.

Keywords

Aceriphyllum rossii

Colonic functional improvement

Dextran sodium sulfate

Inflammatory bowel disease

Ulcerative colitis

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Information

Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
Journal Title :Journal of Agricultural, Life and Environmental Sciences
Journal Title(Ko) :농업생명환경연구
Volume : 35
No :4
Pages :552-563
Received Date : 2023-11-24
Revised Date : 2023-12-04
Accepted Date : 2023-12-06
DOI :https://doi.org/10.22698/jales.20230044

Journal of Agricultural, Life and Environmental Sciences ISSN:2233-8322(Print) 2508-870X(Online) 농업생명환경연구

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