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2021 Vol.33, Issue 3 Preview Page

Research Article

Use of a Korean Wheat Variety to Prevent Myocardial Infarction and Alzheimer’s Disease
Jihye Lee1†
,
Sun-Ha Lim2†
,
Kyeong-Hoon Kim3
,
Chon-Sik Kang3
,
Ji Wook Jung4*
,
Jongwon Lee5*
1Ph.D. Candidate, Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu 41566, Korea
2Research Professor, Department of Biochemistry, School of Medicine, Daegu Catholic University, Daegu 42105, Korea
3Researcher, Wheat Research Team, National Institute of Crop Science, RDA, Wanju 55365, Korea
4Professor, Division of Bio-technology and Convergence, Daegu Haany University, Gyeongsangbuk-do 38578, Korea
5Professor, Department of Biochemistry, School of Medicine, Daegu Catholic University, Daegu 42105, Korea
*Corresponding Author
†These authors contributed equally to this work.
31 December 2021. pp. 391-408
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Abstract

In our previous studies, wheat-extract powder and/or wheat-bran extract powder, processed through centrifugation, showed efficacy in rodent models for Alzheimer’s disease (AD) and myocardial infarction (MI), and improved memory in elderly who complained of memory impairment. However, the development of a new processing method that does not require a centrifugation step is necessary for the efficient and inexpensive processing of functional foods. In this study, we prepared whole-wheat extract powder (WWE) from three Korean wheat varieties: Anbaek, Anzunbaengi, and Goso, by grinding, extraction, and drying. Initially, all three WWEs were tested in a rat MI model and Anbaek WWE was chosen as the final candidate as it significantly reduced myocardial injury even at the lowest dose of 31 mg/kg per day. Additionally, Anbaek wheat flour contained the highest quantity of water-extractable arabinoxylan (WE-AX), an active ingredient, compared to the other varieties tested. Anbaek WWE was then tested in a mouse AD model wherein WWE administration showed maximum memory improvement at a dosage of 125 mg/kg. One underlying mechanism by which Anbaek WWE improved memory was by enhancing neurotransmission at glutamatergic synapses. Based on these results, we recommend Anbaek WWE as a potential candidate to be developed as a functional food to prevent AD and MI at a dosage of 1 g/day per person, which was calculated using a standard conversion factor.

Keywords
Dose
Functional food
Mechanism
Prevention
Screening
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Information
  • Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
  • Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
  • Journal Title :Journal of Agricultural, Life and Environmental Sciences
  • Journal Title(Ko) :농업생명환경연구
  • Volume : 33
  • No :3
  • Pages :391-408
  • Received Date : 2021-12-09
  • Revised Date : 2021-12-13
  • Accepted Date : 2021-12-14
  • DOI :https://doi.org/10.22698/jales.20210039
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