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2021 Vol.33, Issue 3S Preview Page

Research Article

Enhancement of Immune Activation using an Herbal Preparation (Product name: Cheongmokpye)

청목폐(제품명)의 면역 증진 효과

Hee-Jun Kim1
Bohye Kim1
Mi-Ra Lee2
Byung-Kook Sun3
Wang-Kwon Kim4
Bong-Hwan Chung5
Moonjin Ra6
Yongjun Lee7*
김 희준1
김 보혜1
이 미라2
선 병국3
김 왕권4
정 봉환5
라 문진6
이 용준7*
1Senior Researcher, Advanced Materials R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
2Researcher, Advanced Materials R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
3Chief Technical Officer, Koreabestone Corp, Chuncheon 24341, Korea
4Cheif Executive Officer, Koreabestone Corp, Chuncheon 24341, Korea
5Cheif Executive Officer, Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
6Principal Investigator, Natural Products Chemistry R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
7Principal Investigator, Advanced Materials R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
1(재)홍천메디칼허브연구소 신소재개발연구실 선임연구원
2(재)홍천메디칼허브연구소 신소재개발연구실 연구원
3㈜코리아베스트원 연구소장
4㈜코리아베스트원 대표이사
5(재)홍천메디칼허브연구소 소장
6(재)홍천메디칼허브연구소 천연물화학연구실장
7(재)홍천메디칼허브연구소 신소개발연구실장
*Corresponding Author
October 2021. pp. 157-165
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Abstract

An herbal mixture (product name: Cheongmokpye) comprising 20 edible medicinal herbs (including Platycodon grandiflorum, Codonopsis lanceolata, Panax ginseng C. A. Meyer, Morus albaL., Perilla frutescensvar. acuta, and Lilium longiflorum Thunb.) was designed to enhance immune responses and protect against respiratory diseases caused by fine dust and air pollution. We aimed to investigate whether Cheongmokpye extract (TC1) and powder (TC2) treatments enhanced immune activity in RAW 264.7, a murine macrophage-derived cell line. To avoid cytotoxicity arising from TC1 and TC2 treatments, we determined their appropriate dose and found that TC1 and TC2 exhibited no cytotoxicity at doses below 400 µg/ml. Moreover, TC1 and TC2 treatments affected nitric oxide production and pro-inflammatory cytokine (tumor necrosis factor-α, interleukin-1β, and interleukin-6) levels. Moreover, we found that both TC1 and TC2 treatments enhanced the phagocytosis of prelabeled zymosan particles. Collectively, these findings indicate that Cheongmokpye is a beneficial functional food that enhances immune activation and exerts immunostimulatory effects on macrophages.

Keywords
Cheongmokpye
Immune activation
Phagocytosis
Pro-inflammatory cytokines
Respiratory disease prevention
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Information
  • Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
  • Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
  • Journal Title :Journal of Agricultural, Life and Environmental Sciences
  • Journal Title(Ko) :농업생명환경연구
  • Volume : 33
  • No :3
  • Pages :157-165
  • Received Date :2021. 09. 24
  • Revised Date :2021. 10. 05
  • Accepted Date : 2021. 10. 07
  • DOI :https://doi.org/10.22698/jales.20210016
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