Effects of Blue Spirulina on Acute Colitis Induced by Dextran Sodium Sulfate in Mice

Mi-Ra Lee; Bohye Kim; Hee-Jun Kim; Jeong-Wook Jeon; Eun-Young Kim; Moonjin Ra; Bong-Hwan Chung; Yongjun Lee

doi:10.22698/jales.20210022

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2021 Vol.33, Issue 3S Preview Page Next Page

Research Article

Effects of Blue Spirulina on Acute Colitis Induced by Dextran Sodium Sulfate in Mice 블루 스피루리나의 궤양성 대장염 개선효과

31 October 2021. pp. 215-224

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Abstract

Spirulina (Arthrospira platensis) is a blue-green microalga with bioactive molecules. Blue spirulina is a phycocyanin extracted from spirulina. We investigated the protective effects of spirulina (SP) and blue spirulina (BS) on a dextran sulfate sodium (DSS)-induced colitis mice. SP or BS was administered orally at 100 and 400 mg/kg/day, respectively for 12 days, and colitis was induced by oral gavage with 2.5% DSS for 5 days on the 8th day. DSS-induced colitis mice showed severe bloody stools, diarrhea, weight loss, and colon shortening. However, SP and BS treatments improved the disease activity index (DAI) score and colon length. The improvement of colitis symptoms was validated by reduced levels of proinflammatory cytokines such as TNF-α, IL-6, and IL-1β. Moreover, SP and BS significantly reduced colonic myeloperoxidase and prostaglandin E2 activities in DSS-induced colitis. These results suggest that SP and BS have protective potential against DSS-induced colitis by suppressing excessive inflammatory response. The findings of this study suggest that SP and BS have substantial potential for the treatment of inflammatory colitis.

Keywords

Colitis

Dextran sulfate sodium

Inflammatory bowel disease

Phycocyanin

Spirulina

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Information

Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
Journal Title :Journal of Agricultural, Life and Environmental Sciences
Journal Title(Ko) :농업생명환경연구
Volume : 33
No :3
Pages :215-224
Received Date : 2021-10-05
Revised Date : 2021-10-19
Accepted Date : 2021-10-20
DOI :https://doi.org/10.22698/jales.20210022

Journal of Agricultural, Life and Environmental Sciences ISSN:2233-8322(Print) 2508-870X(Online) 농업생명환경연구

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