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2021 Vol.33, Issue 3S Preview Page

Research Article

Effect of Wolfiporia extensa, Atractylodes japonica, and Paeonia lactiflora Extracts and Their Mixtures on Improving Hepatic Function and Hepatocyte Protection

복령, 백출, 작약 단독 및 혼합 추출물의 간건강 개선효과

Hee-Jun Kim1
Bohye Kim1
Mi-Ra Lee2
Chang-Eun Kim3
Soo-Hyun Kim4
Bong-Hwan Chung5
Moonjin Ra6
Yongjun Lee7*
김 희준1
김 보혜1
이 미라2
김 창은3
김 수현4
정 봉환5
라 문진6
이 용준7*
1Senior Researcher, Advanced Materials R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
2Researcher, Advanced Materials R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
3Researcher, Guwoonfood, Hoengseong 25246, Korea
4Chief Technical Officer, Guwoonfood, Hoengseong 25246, Korea
5Cheif Executive Officer, Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
6Principal Investigator, Natural Products Chemistry R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
7Principal Investigator, Advanced Materials R&D Dept., Hongcheon Institute of Medicinal Herb, Hongcheon 25142, Korea
1(재)홍천메디칼허브연구소 신소재개발연구실 선임연구원
2(재)홍천메디칼허브연구소 신소재개발연구실 연구원
3구운식품 연구원
4구운식품 연구소장
5(재)홍천메디칼허브연구소 소장
6(재)홍천메디칼허브연구소 천연물화학연구실장
7(재)홍천메디칼허브연구소 신소개발연구실장
*Corresponding Author
†These authors contributed equally to this work.
October 2021. pp. 205-214
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Abstract

Herbal preparations are combinations of botanical extracts that are assumed to exert additive and synergistic effects. In this study, we investigated the effects of individual ethanol extracts of Wolfiporia extensa (TD1), Atractylodes japonica (TD2), Paeonia lactiflora (TD3), and mixtures thereof (TD4–TD7) on improvements in hepatic function and hepatocyte protection in human hepatocyte carcinoma (HepG2) cells. Prior to this experiment, we determined the appropriate dose for the treatment using TD1, TD2, TD3, and TD4–TD7 on the viability of HepG2 cells. Results showed that these extracts ameliorated cell toxicity against acetaminophen (APAP)-induced cell death in human hepatocyte carcinoma cells. Additionally, they significantly reduced lactate dehydrogenase (LDH) levels. We also evaluated the effect of TD1–TD7 on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. We found that treatment with TD1–TD7 slightly attenuated the increase in AST and ALT levels compared to APAP-treated HepG2 cells. These results indicate that Wolfiporia extensa, Atractylodes japonica, and Paeonia lactiflora extracts and their mixtures could help improve hepatic function and induce hepatocyte protection.

Keywords
Atractylodes japonica
Hepatic function
Hepatocyte protection
Paeonia lactiflora
Wolfiporia extensa
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Information
  • Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
  • Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
  • Journal Title :Journal of Agricultural, Life and Environmental Sciences
  • Journal Title(Ko) :농업생명환경연구
  • Volume : 33
  • No :3
  • Pages :205-214
  • Received Date :2021. 09. 24
  • Revised Date :2021. 10. 16
  • Accepted Date : 2021. 10. 18
  • DOI :https://doi.org/10.22698/jales.20210021
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