Improvement Effects of Prunus Davidiana (Carrière) Franch. Extract on Ulcerative Colitis

Bohye Kim; Hee-Jun Kim; Mi-Ra Lee; Gye Chun Jo; Moonjin Ra; Yongjun Lee

doi:10.22698/jales.20230048

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2023 Vol.35, Issue 4 Preview Page Next Page

Research Article

Improvement Effects of Prunus Davidiana (Carrière) Franch. Extract on Ulcerative Colitis 산복사나무 추출물의 궤양성 대장염증 완화 검증

31 December 2023. pp. 593-603

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Abstract

Prunus Davidiana, known as wild peach, has been used as a medicinal material against various inflammatory diseases since ancient times and belongs to the family Rosaceae. This study aimed to investigate the effect of wild peach extract (WPE) on inflammatory bowel diseases IBD at two different doses (10 and 100 mg/kg). Colitis was induced in mice (C57BL/6) by administering 2.0% Dextran sodium sulfate (DSS) in drinking water for 5 days. WPE treatment significantly improved the disease activity index, addressing symptoms such as body weight loss, bloody stool, stool consistency, and colon shortening. Furthermore, the increased levels of myeloperoxidase and pro-inflammatory cytokines (IL-6 and IL-22) with the development of colitis following DSS administration were significantly decreased by WPE. Histological analysis with Hematoxylin & Eosin staining of the colon tissue suggested that WPE significantly reduced colon damage. Additionally, pro-inflammatory cytokine (IL-8) and reactive oxygen species levels were reduced in HT-29 cells. Based on these results, we suggest that P. davidiana can ameliorate DSS-induced colitis in a mouse model. Furthermore, we anticipate that P. davidiana could serve as an effective therapeutic candidate for the treatment of inflammatory bowel diseases.

Keywords

Dextran sulfate sodium

Inflammatory bowel disease

Prunus Davidiana (Carrière) Franch

Ulcerative colitis

Wild peach

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Information

Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
Journal Title :Journal of Agricultural, Life and Environmental Sciences
Journal Title(Ko) :농업생명환경연구
Volume : 35
No :4
Pages :593-603
Received Date : 2023-11-24
Revised Date : 2023-12-06
Accepted Date : 2023-12-07
DOI :https://doi.org/10.22698/jales.20230048

Journal of Agricultural, Life and Environmental Sciences ISSN:2233-8322(Print) 2508-870X(Online) 농업생명환경연구

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